tSoil borne fungal diseases pose serious constraints on agro-productivity. Biological control is non-hazardous strategy to control plant pathogens and improve crop productivity. PGPR (plant growthpromoting rhizobacteria) have long been used as plant disease control agents. PGPR produced a widerange of secondary compounds that may act as signals—that is, allelochemicals that include metabolites,siderophores, antibiotics, volatile metabolites, enzymes and others. Their mode of action and molecularmechanisms provide a great awareness for their application for crop disease management. The presentreview highlights the role of PGPR strains, specifically referring to allelochemicals produced and molecu-lar mechanisms. Further research to fine tune combinations of allelochemicals, plant-microbe–pathogeninteraction will ultimately lead to better disease control.