After 10 different of endophytic microbial were isolated from M. alba explant. Medium extract of endophytic fungus isolated from M. alba (identified as Trichoderma sp.) can inhibit α-glucosidase (IC50 = 0.81±0.12 mg crude extract/mL), tyrosinase enzymes (IC50 = 3.72±0.58 mg crude extract/mL). It also showed a positive mulberroside A accumulation (0.40 mg/g crude extract). While others microbial medium showed the negative results. This study can’t be concluded that Trichoderma sp.