The mode of action of mosquito repellents remains a controversial topic. However, electrophysiological
studies and molecular approaches have provided a better understanding of how repellents exert their
effects. Here, we briefly discuss various theories of repellent action and present the current status of
knowledge of the effects of repellents on olfactory and gustatory processes. These findings provide a
framework for further development of existing repellents and the discovery of new compounds with
novel modes of action.
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