Foreign proteins can be synthesised using microbial cell
culture, animal cell culture, plant tissue culture, transgenic
animals and transgenic plants. Choosing the most appropriate
method for commercial production requires
case-by-case analysis. A wide range of factors must be considered,
including cost of production, market volume, the
efficacy, safety and stability of the product, and whether
the foreign protein has different biochemical or pharmacological
properties compared with material from existing
sources. Although most interest during the past 15–20
years has been focused on microbial and animal cell cultures,
plants and plant cells are now considered as viable
and competitive expression systems for large-scale protein
production. The development of transgenic plants and
plant viral vectors for foreign protein synthesis has been
reviewed extensively [1•,2–6].
Foreign proteins can be synthesised using microbial cell
culture, animal cell culture, plant tissue culture, transgenic
animals and transgenic plants. Choosing the most appropriate
method for commercial production requires
case-by-case analysis. A wide range of factors must be considered,
including cost of production, market volume, the
efficacy, safety and stability of the product, and whether
the foreign protein has different biochemical or pharmacological
properties compared with material from existing
sources. Although most interest during the past 15–20
years has been focused on microbial and animal cell cultures,
plants and plant cells are now considered as viable
and competitive expression systems for large-scale protein
production. The development of transgenic plants and
plant viral vectors for foreign protein synthesis has been
reviewed extensively [1•,2–6].
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