One possible explanation is that other
regions of brain, such as transentorhinal, parahippocampal
gyrus and entorhinal cortexes, which also play a critical
role in the neural control of cognitive function [31],
may also be affected by hypoxemic insults and systemic
inflammatory stress with the progress of the disease.
Therefore, there was no lineary correlation between hippocampal
atrophy and cognitive impairment in the later
stage of the dise