Abstract As selenium in the form of “Selenoprotein W (SelW)” is essential for the
maintenance of normal liver function, the expression of SelW liver depends on the level of
selenium supplied with the diet. Whereas this is well known to be the case in mammals,
relatively little is known about the effect of dietary Se on the expression SelW in the livers
of avian species. To investigate the effects of dietary Se levels on the SelW mRNA
expression in the liver of bird, 1-day-old male chickens were fed either a commercial diet or
a Se-supplemented diet containing 1.0, 2.0, 3.0, and 5.0 mg/kg sodium selenite (Na2SeO3)
for 90 days. The livers were collected and examined for Se content and mRNA levels of
SelW, Selenophosphate synthetase-1, and selenocysteine-synthase (SecS). The data indicate
that, within a certain range, a Se-supplemented diet can increase the expression of SelW and
the mRNA levels of SecS, and also, that the transcription of SelW is very sensitive to
dietary Se.
Abstract As selenium in the form of “Selenoprotein W (SelW)” is essential for themaintenance of normal liver function, the expression of SelW liver depends on the level ofselenium supplied with the diet. Whereas this is well known to be the case in mammals,relatively little is known about the effect of dietary Se on the expression SelW in the liversof avian species. To investigate the effects of dietary Se levels on the SelW mRNAexpression in the liver of bird, 1-day-old male chickens were fed either a commercial diet ora Se-supplemented diet containing 1.0, 2.0, 3.0, and 5.0 mg/kg sodium selenite (Na2SeO3)for 90 days. The livers were collected and examined for Se content and mRNA levels ofSelW, Selenophosphate synthetase-1, and selenocysteine-synthase (SecS). The data indicatethat, within a certain range, a Se-supplemented diet can increase the expression of SelW andthe mRNA levels of SecS, and also, that the transcription of SelW is very sensitive todietary Se.
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