Bitter melon and metformin were well tolerated in our study.
There was a low incidence of important gastrointestinal adverse
effects with metformin in this study because the dosage of metformin
was slowly titrated. However, some patients experienced an
increased appetite with 2000 mg/day of bitter melon. Importantly,
we would not recommend bitter melon in patients with abnormal
liver function or liver diseases because one patient experienced an
elevation of liver enzymes from baseline.