For example, we recently dissected resistance and tolerance to rodent malaria in laboratory mice [9].
Using anaemia and weight loss as measures of the effects of infection on host health, and measures of parasite densities to estimate host resistance, we were able to formally show that in addition to the well-known genetic variation in resistance to malaria, there is also genetic variation in tolerance.
Interestingly, although we worked with only five mouse strains, there was nonetheless a perfect negative relationship between tolerance and resistance: those mouse strains that most controlled their parasite burdens (i.e., high resistance) were those whose health was most affected by small changes in parasite burden (i.e., low tolerance).