Lead interferes with the function of enzymes and essential cations
(particularly calcium) in cells throughout the body /1-3/, and lead
poisoning is usually associated with multi-systemic signs and
symptoms /4-5/. The metal causes proximal renal tubular damage,
characterized by generalized aminoaciduria, hypophosphatemia, with
relative hyperphosphaturia and glycosuria accompanied by nuclear
inclusion bodies, mitochondrial changes, and cytomegaly of the
proximal tubular epithelial cells /1 -2/. Lead also affects normal liver
functions, impairs the detoxification of xenobiotics (environmental
toxins and drugs), alters tryptophan metabolism, and elevates
serotonin and hydroxy indole acetic acid in brain, resulting in
disturbed neurotransmitter functions /1-2 /.
Lead interferes with the function of enzymes and essential cations(particularly calcium) in cells throughout the body /1-3/, and leadpoisoning is usually associated with multi-systemic signs andsymptoms /4-5/. The metal causes proximal renal tubular damage,characterized by generalized aminoaciduria, hypophosphatemia, withrelative hyperphosphaturia and glycosuria accompanied by nuclearinclusion bodies, mitochondrial changes, and cytomegaly of theproximal tubular epithelial cells /1 -2/. Lead also affects normal liverfunctions, impairs the detoxification of xenobiotics (environmentaltoxins and drugs), alters tryptophan metabolism, and elevatesserotonin and hydroxy indole acetic acid in brain, resulting indisturbed neurotransmitter functions /1-2 /.
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