O.N., a 40-year-old white male with hypercholesterolemia, has had appropriate low-density lipoprotein levels by taking 40 mg pravastatin daily along with acontrolled diet. His normal dietary routine includes a breakfast of cereal, low-fatmilk, decaffeinated coffee, and orange juice each morning; salad for lunch; a sensible dinner; and an evening snack of grapefruit juice and graham crackers. Withthe turning of the year, O.N.’s health maintenance organization sends a letterstating that pravastatin will no longer be covered by his prescription plan; however, atorvastatin and simvastatin will be covered. O.N.’s physician switches himto 20 mg daily of simvastatin.