In the late 1930s, the chapel was ornamented with fifty-seven superb frescoes painted by José Clemente Orozco, one of the greatest Mexican muralists of the time. These works are considered a great masterpiece of Mexican art and illustrate both Spanish culture as well as Mexico’s indigenous culture with gods, sacrifices and temples. The focus of the murals is found in the chapel’s dome with the work El Hombre de Fuego (The Man of Fire) which represents the submission of humans to machines.
Currently, the hospice is the home of the Cabañas Cultural Institute and the Cultural Heritage of Humanity. A buffer zone of 18 urban blocks measuring 37.26 hectares surrounds the complex bounded by Federacion Street in the north, Javier Mina in the south, Mariano Jiménez in the east and on the west Calzada Independencia.