The lung-protective ventilation strategy is both safe
and potentially beneficial in patients who do not have
ARDS at the onset of mechanical ventilation. In mechanically
ventilated patients without ARDS at the time of
endotracheal intubation, the majority of data favors
lower tidal volume to reduce progression to ARDS [23].
Septic patients without ARDS who were ventilated
with a protective strategy using a plateau pressure