Replacing sodium chloride by salt substitutes in the recipe is one of the main strategies applied in the
food industries to prevent unwanted health effects into population. However the reduction in NaCl may
affect to the oxidative balance and the formation of process contaminants in the food, besides of
sensorial and technological aspects already known. The effect of replacing NaCl by different salts and two
commercial salt-replacers on the formation of acrylamide and furfurals, as well as the influence on the
lipid oxidation after storage was evaluated in a cookie model. Acrylamide content was reduced by up to
58% in the cookie containing CaCl2 and 35e40% when NaCl was partly substituted by commercial saltreplacers.
Hydroxymethylfurfural and furfural content did not greatly varied by the recipe, except by
CaCl2, which significantly increased the furfurals formation. Although no significant relationship was
found between mineral composition and lipid oxidation after storage, products of lipids oxidation were
detected. In conclusion, the type of salts used in the cookie recipe affects the extent of lipid oxidation and
the formation of process contaminants and, therefore, these potential side effects should be carefully
considered by the food industries when implementing sodium reduction strategies in their products.