These studies demonstrated the importance of insulin resistance and the renin–angiotensin system for weight lossinduced
BP reduction associated with aerobic exercise, however, these studies did not compare neurohormonal changes during the acute phase of weight loss. In the present study, at the early stage of weight loss, before significant weight loss at 8 weeks, suppression on plasma NE followed by a decrease in HOMA-IR and BP reduction was observed in the D alone group, whereas significant reduction in HOMA-IR followed by suppression on sympathetic nervous activity and BP reduction occurred in the EX alone group.