New high-efficient light delivery technologies, for example, optical fibers, and optical clearing techniques, should be investigated to improve the penetration of UV irradiation in human skin and tissue. With the development of novel high-technology UV sources, using an NB wavelength range or a mono wavelength, such as LED, lasers, and microwave-generated UV plasma for UV phototherapy, will become as efficient biomedical modalities for the treatment of different localized and systemic dermatological disorders.