Curcumin shows strong anti-oxidation and anti-inflammatory activities. In the past two decades over 7000 articles have discussed the molecular basis of curcumin’s attributed antioxidant, anti-inflammatory, antibacterial, antiapoptosis, anticancer and related activities. Over 100 clinical trials have focused on the role of curcumin in various chronic diseases, including diabetes and cancers, as well as autoimmune, cardiovascular, neurological and psychological diseases [8]. In this review we try to clarify the possible link between curcumin, inflammation and chronic diseases.