5.4.1 MucolyticsMucolytic agents su

5.4.1 Mucolytics
Mucolytic agents such as bromhexine and dembrexine
reduce mucus viscosity in the tracheobronchial tree and are
often prescribed for chronic bronchitis in dogs, bronchopneumonia
in cattle, and chronic coughing in horses. The
rationale for their use is that mucus of lower viscosity is
more easily carried up the tracheobronchial tree by the
mucociliary clearance mechanism and expectorated during
coughing. Ambroxol is a metabolite of bromhexine and has
similar actions.
Acetylcysteine is a mucolytic agent that reduces the viscosity
of secretions probably by the splitting of disulfide bonds
in mucoproteins. It is also used to detoxify an intermediate
paracetamol metabolite that is present in paracetamol overdosage
(see Treatment of poisoning).
In small animals inhalation of water vapour and chest physiotherapy
are effective methods of mucus removal.
BROMHEXINE
UK
Indications. Respiratory disease where excess tenacious
mucus is present
Dose.
Horses: by mouth, 200–400 micrograms/kg once daily
Cattle: by mouth or by intramuscular injection, 500 micrograms/
kg once daily
Pigs: by mouth or by intramuscular injection, 200–500
micrograms/kg once daily
Dogs: by mouth, 2 mg/kg twice daily
Cats: by mouth, 1 mg/kg once daily
POM Bisolvon (Boehringer Ingelheim) UK
Oral powder, for addition to feed or drinking water, bromhexine hydrochloride
10 mg/g, for horses, cattle, pigs, dogs, cats
Withdrawal Periods. Should not be used in horses intended for human consumption.
Cattle: slaughter 1 day, should not be used in cattle producing milk
for human consumption. Pigs: slaughter withdrawal period nil
Injection, bromhexine hydrochloride 3 mg/mL, for cattle, pigs
Withdrawal Periods. Cattle: slaughter 3 days, should not be used in cattle
producing milk for human consumption. Pigs: slaugher withdrawal period
nil
DEMBREXINE HYDROCHLORIDE
UK
Indications. Respiratory disease where excess or tenacious
mucus is present in the airways
Contra-indications. Animals with hypersensitivity to
dembrexine
Dose. Horses: by mouth, 300 micrograms/kg twice daily
POM Sputolosin (Boehringer Ingelheim) UK
Oral powder, for addition to feed, dembrexine hydrochloride 5 mg/g, for
horses
Withdrawal Periods. Slaughter 1 day

ผลลัพธ์ (ไทย) 3:

5.4.1 mucolytics ผู้บัญชาการ ทหารเรือ เช่น กุหลาบมอญ dembrexine
ลดความหนืดและเมือกใน tracheobronchial ต้นไม้และ
มักจะกำหนดให้โรคหลอดลมอักเสบเรื้อรังในสุนัข สะดือ
ในโค และไอเรื้อรัง ในม้า
เหตุผลในการใช้ของพวกเขาคือเมือกของความหนืดลดลงได้อย่างง่ายดาย อุ้มขึ้น

tracheobronchial โดยต้นไม้mucociliary clearance mechanism and expectorated during
coughing. Ambroxol is a metabolite of bromhexine and has
similar actions.
Acetylcysteine is a mucolytic agent that reduces the viscosity
of secretions probably by the splitting of disulfide bonds
in mucoproteins. It is also used to detoxify an intermediate
paracetamol metabolite that is present in paracetamol overdosage
( เห็นการรักษาพิษ ) .
ในสัตว์ขนาดเล็กการสูดไอน้ำ และการทำกายภาพบำบัดทรวงอก
เป็นวิธีที่มีประสิทธิภาพในการกำจัดเมือก กุหลาบมอญอังกฤษ


ข้อบ่งชี้ โรคทางเดินหายใจที่เมือกเหนียวเกินอยู่


ขนาด ม้า : ปาก , 200 – 400 ไมโครกรัม / กิโลกรัมวันละ
โค : โดยปากหรือฉีด 500 ไมโครกรัม / กิโลกรัมวันละ

หมู : by mouth or by intramuscular injection, 200–500
micrograms/kg once daily
Dogs: by mouth, 2 mg/kg twice daily
Cats: by mouth, 1 mg/kg once daily
POM Bisolvon (Boehringer Ingelheim) UK
Oral powder, for addition to feed or drinking water, bromhexine hydrochloride
10 mg/g, for horses, cattle, pigs, dogs, cats
Withdrawal Periods. Should not be used in horses intended for human consumption.
Cattle: slaughter 1 day, should not be used in cattle producing milk
for human consumption. Pigs: slaughter withdrawal period nil
Injection, bromhexine hydrochloride 3 mg/mL, for cattle, pigs
Withdrawal Periods. Cattle: slaughter 3 days, should not be used in cattle
producing milk for human consumption. Pigs: slaugher withdrawal period
nil
DEMBREXINE HYDROCHLORIDE
UK
Indications. Respiratory disease where excess or tenacious
mucus is present in the airways
Contra-indications. Animals with hypersensitivity to
dembrexine
Dose. Horses: by mouth, 300 micrograms/kg twice daily
POM Sputolosin (Boehringer Ingelheim) UK
Oral powder, for addition to feed, dembrexine hydrochloride 5 mg/g, for
horses
Withdrawal Periods. Slaughter 1 day