Comparing baseline THR evaluations to those conducted post-THR intervention, participants demonstrated significant
improvements on the ABC-C Irritability (p < 0.001), Lethargy (p < 0.001), Stereotypic Behavior (p < 0.001), Hyperactivity (p < 0.001) and Inappropriate Speech (p = 0.05) scales, From repeated measures ANOVA analysis using a linear mixed-effects model, analysis of the weekly parent/legal guardian reports for the ABC-C demonstrated that the behaviors measured improved over the course of the THR intervention. For the Irritability, Lethargy, Stereotypic Behavior and Hypersensitivity scales, statistically significant improvement was noticed as early as the third week of THR (Fig. 2). Measures at every subsequent week were significantly different from baseline. The improvement reached the maximum level around week five and stabilized over the rest of the THR intervention period.