FIG. 1. Protein sequence of the Octopus ER. The aligned sequences
of the Octopus ER and selected other steroid and related receptors are
shown. The DBD and LBD are marked with black boxes. The Nterminal
domain, which is inadequately conserved to align, is not
shown. Residues important for DNA response element recognition
(the P-box) is shaded gray, as is the AF-2 region, which mediates the
LBD’s contact with transcriptional coactivators. Residues composing
the helices of the human ER-LBD are underlined. Residues that line
the ligand cavity in the humanER crystal structure are marked with
filled circles, and those that form hydrogen bonds with estradiol are
noted with asterisks (30, 31).