A powerful AGE inhibitor, aminoguanidine, has been
developed as a treatment of diabetic nephropathy.
However, reported side effects including vasculitis and
abnormalities in liver function were associated with its
long-term administration in human and less toxic agents
are desirable [5]. Natural compounds, especially flavonoids
and polyphenolic substances which are present in
common foodstuffs and spices, have been demonstrated
to inhibit protein glycation [6-8]. Investigation of their
activity on AGEs should therefore offer a potential in the
prevention and reduction of diabetic complications.