A total of 1441 patients were assessed for eligibility; of these patients, 535 (37.1%) from 88 sites in the United States were enrolled in the trial between October 2011 and May 2013 (Fig. S1A and Fig. S1B in the Supplementary Appendix).
A total of 1441 patients were assessed for eligibility;of these patients, 535 (37.1%) from 88 sitesin the United States were enrolled in the trialbetween October 2011 and May 2013 (Fig. S1Aand Fig. S1B in the Supplementary Appendix).