I have presented just a few examples of how changes
in charge distribution caused by substituents can modify the properties and reactions of organic compounds. Hydrogen bonding, is of course, one of the more familiar of the electrostatic interactions. There are many other recent examples, such as in the control of the stereochemistry of additions to double or triple bonds (43), in the control of reactivity in antibiotic binding to DNA in controlling the properties of polypeptides (46), and in explaining the unusual acidity of carbon acids in enzyme-catalyzed reactions (47). These are just a few examples. In fact, much of chemistry is at least partially controlled by electrostatic interactions