In the race between DNA sequencing throughput and computer speed, sequencing is winning by a mile. Sequencing throughput has recently been improving at a rate of about 5-fold per year, while computer performance generally follows “Moore's Law,” doubling only every 18 or 24 months. As this gap widens, the question of how to design higher-throughput analysis pipelines becomes critical. If analysis throughput fails to turn the corner, research projects will continually stall until analyses catch up.