It has been stated that insulin-like growth factor II and mannose-6-phosphate bind
to the same receptor on the fibroblast (WESTLUND et al., 1991). These two ligands activate the fibroblasts to enhance the wound healing process. An important criterion that might make SUBRAMANIAN et al. (2006) and MOGHBEL et al. (2007) findings different from the finding of the present study is that they applied the gel for longer time. SUBRAMANIAN et al. (2006) applied the gel twice a day for a period of 14 days and MOGHBEL et al. (2007)applied the gel twice a day for 18 days, while in the present experiment the AAvE was applied once a day for five days.