Recently, a cost effective and relatively higher throughput rat
pH dependent absorption model has been reported (Lubach et al.,
2013). In this model, effect of pentagastrin (0.25 mg/kg, sc) and
famotidine (10 mg/kg, iv) pretreatment on rat gastric pH was evaluated
and compared with control rats. The gastric pH of control
rats was approximately 2.0; whereas after pentagastrin pretreatment
gastric pH was ranging from 1.3 to 2.9 over the 6 h time period.
Famotidine increased the gastric pH, ranging from 4.0 to 5.2