Heat shock might disturb the cellular homeostasis and expression
of a specific proteins resulted in the increase of stress
proteins (Rajdev and Sharp, 2000). Upregulation of these proteins
could be used as biomarkers for the evaluation HS with the physiological
markers. To the best of our knowledge, this is the first
study to provide insight into the differential expression of proteins
in the mouse pituitary gland under HS and to provide a baseline
for understanding the role of stress-related proteins and the associations
of the HSPs with intermediate filament proteins. Here,
we report important biomarkers of HS and neurotoxicity. Our
findings suggest that proteins that are differentially expressed
under HS play important roles in combating HS. The functional
correlations of these differentially expressed proteins under HS,
particularly between HSPs and intermediate filament proteins,
require further study