stenosis. Of these 21 segments ICA classified 10 segments
with 25-49 % stenosis and the remaining 11 segments
without any stenosis (≤24 % lumen reduction). All these
21 segments were found to have either severe calcifications
or a combination of calcifications and minor artifacts
on CCTA.
In a per patient analysis, 17 % (8 of 48) had at least
one stenosis ≥50 % in any segment at ICA. CCTA correctly
identified all these patients, corresponding to a
sensitivity of 100 %. Specificity was 78 %, positive predictive
value 47 %, and negative predictive value 100 %.
Estimated Kappa was 0,53, giving moderate agreement
between the methods.
At the maximum exercise test, the mean achieved
work capacity was 143 ± 44 Watts. 15 patients (31 %)
had signs of silent ischemia with positive or inconclusive
test. When comparing silent ischemia as detected on the
maximum exercise test versus CCTA and ICA estimated
Kappa were 0,16 and 0,17 respectively, yielding poor