The essential oil of the rhizome of Zingiber cassumunar was found to exhibit a topical anti-inflammatory effect, when tested using the model of carrageenan-induced hind paw edema in rats (ID50 = 22 mg oil/paw). Individual assessment of topical antiinflammatory activity of the five major component s of th e oil demonstrated that (E)-1-(3,4-dimethoxyphenyl)buta diene (OMPBO), terpinen-4-ol and rz-terpinene significantly inhibited edem a formation, whereas sabinene and Y terpinene were inactive up to 6 mg/paw. The most active compound, DMPBD, was found to be an antiinflammatory agent twice as potent as the reference drug diclofenac (1050 = 3 vs 6 mg/paw, respectively).
The essential oil of the rhizome of Zingiber cassumunar was found to exhibit a topical anti-inflammatory effect, when tested using the model of carrageenan-induced hind paw edema in rats (ID50 = 22 mg oil/paw). Individual assessment of topical antiinflammatory activity of the five major component s of th e oil demonstrated that (E)-1-(3,4-dimethoxyphenyl)buta diene (OMPBO), terpinen-4-ol and rz-terpinene significantly inhibited edem a formation, whereas sabinene and Y terpinene were inactive up to 6 mg/paw. The most active compound, DMPBD, was found to be an antiinflammatory agent twice as potent as the reference drug diclofenac (1050 = 3 vs 6 mg/paw, respectively).
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