Primary prophylaxis in hemophilia patients has proved to be effective in preventing complications by administrating periodic factor replacement. Primary prophylaxis involves the infusion of factor VIII concentrate on a regular basis before the onset of joint damage. Secondary prophylaxis involves the infusion of factor. VIII concentrate on a regular basis after the child experiences his or her first joint bleed. The infusions are given three times a week. Aggressive factor replacement may be a cost-effective alternative to primary prophylaxis. This involves the infusion of a high dose of factor VIII concentrate when a joint bleed occurs, followed by 2 day of more standard doses of factor VIII concentrate with consideration of additional treatment every other day for one week.