The storyline is the culmination of events from Silver Surfer vol. 3, #34 (Feb. 1990) and the two-issue miniseries The Thanos Quest (Sept.- Oct. 1990).
In 1991, artist George Pérez signed on to pencil the six-issue limited series. However, due to the emotional stresses Pérez was suffering from related to his concurrent work as writer/artist on DC Comics' Wonder Woman and as artist on the DC limited series War of the Gods,[1] Pérez was unable to finish penciling each issue of Infinity Gauntlet. Pérez left the project while working on issue #4, with penciler Ron Lim assigned to replace him. Pérez remained as the inker over Lim's cover art for the remainder of the miniseries.
Additional plotlines not addressed in the main story were featured in other books published during the same time period.
The storyline led to two sequel miniseries, Infinity War and Infinity Crusade. All three series were the core of a company-wide crossover story.