Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.
Lee, J., Blaber, M.
Journal: (2011) Proc.Natl.Acad.Sci.USA 108: 126-130
PubMed: 21173271
PubMedCentral: PMC3017207
DOI: 10.1073/pnas.1015032108
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PubMed Abstract:
The majority of protein architectures exhibit elements of structural symmetry, and "gene duplication and fusion" is the evolutionary mechanism generally hypothesized to be responsible for their emergence from simple peptide motifs. Despite the central importance of the gene duplication and... [ Read More & Search PubMed Abstracts ]