Fermentation by micro-organisms results in a lowering of the pH. As a non-fermented 10 composition, สูตรmay have a pH above 5.5, such as 6.0, such as 6.5 (for
example, in order to reduce damage to teeth). The pH may ที่เหมาะสมคือ be between 6 and 8.
สูตรmay be formulated to reduce stool irregularities (e.g., hard stools,
insufficient stool volume, diarrhoea), which is a major problem in many babies. The
สูตรmay be administered in the fowl of a liquid สูตรwhich has an osmolality 15 between 50 and 500 mesm/kg, such as between 100 and 400 mOsm/kg.
สูตรmay be administered in the form of a liquid สูตรwith a viscosity between 1 and 60 mPa.s, such as between 1 and 20 mPa.s, such as between 1 and 10 mPa.s, such as between 1 and 6 mPa.s. The low viscosity ensures a proper
administration of the liquid, e.g., a proper passage through the hole of a nipple in a 20 nursing bottle. Also, this viscosity closely resembles the viscosity of human milk.
Furthermore, a low viscosity results in a normal gastric emptying and a better energy
intake, which is essential for infants that need the energy for optimal growth and
development. The viscosity of the liquid may be determined using a Physica
Rheometer MCR 300 (Physica Messtechnik GmbH, Ostfilden, Germany) at shear rate
25 of 95 sri at 20 °C.
สูตรmay be formulated so that it does not have an excessive caloric
density. Hence, สูตร (in liquid form) may have a caloric density between 0.1 and 2.5 kcal/mL, such as a caloric density of between 0.4 and 1.2 kcal/mL, such as between 0.55 and 0.75 kcal/mL.
30 สูตรmay have a long shelf life. For example, it may be shelf stable at
ambient temperature forอย่างน้อย6 months, such as least 12 months, where it is in a liquid, ready-to-feed form or where it is in a powder form.
32
BALANCED GROWTH และ/หรือ DEVELOPMENT
As described herein, the present inventors have developed optimised amino acid
profiles and formulations suitable to achieve these profiles. The formulations are
proposed to promote balanced growth และ/หรือ development in an infant, และ/หรือ to
5 prevent or reduce the risk of unbalanced growth และ/หรือ development in an infant.
The term "balanced" as used in the phrase "balanced growth และ/หรือ development"
is intended to refer to healthy or normal growth และ/หรือ development of an infant. For
example, the growth และ/หรือ development is not too low/little or too high/much
("unbalanced growth และ/หรือ development"). This may be with reference to published 10 figures that define the healthy or normal growth และ/หรือ development of an infant with
reference to a population (geographic, demographic, ethnic, etc) within which the
infant belongs, หรือ with reference to the growth และ/หรือ development an unhealthy infant
or group of unhealthy infants. Examples of published references include the WHO
growth curve (WHO, 2006).
15 The term "growth และ/หรือ development" as used herein may refer to growth และ/หรือ
development of the brain of an infant และ/หรือcognitive function of the infant, as further defined below, และ/หรือ to growth และ/หรือ development of the body of an infant และ/หรือinfant's body composition, also as further defined below.
According to one ลักษณะ of the การประดิษฐ์นี้, there is provided a สูตรas
20 defined herein for use in promoting, assisting or achieving balanced growth or
development in an infant. Also provided is the use of a composition in the manufacture of a สูตรas defined herein for promoting, assisting or achieving balanced growth or development in an infant. Also provided is a method for promoting, assisting or
achieving balanced growth or development in an infant, โดยที่ the method ประกอบรวมด้วย 25 administering to the infant a สูตรas defined herein.
As another ลักษณะ of the การประดิษฐ์นี้, there is provided a สูตรas defined herein for use in preventing or reducing the risk of unbalanced growth or development in an infant. Also provided is the use of a composition in the manufacture of a สูตรas defined herein for preventing or reducing the risk of unbalanced growth or
30 development in an infant. Also provided is a method for preventing or reducing the
risk of unbalanced growth or development in an infant, โดยที่ the method ประกอบรวมด้วย administering to the infant a สูตรas defined herein.
33
As a further ลักษณะ of the การประดิษฐ์นี้, there is provided a สูตร(i) for use in promoting, assisting or achieving balanced growth or development in an infant
และ/หรือ for use in preventing or reducing the risk of unbalanced growth or development in an infant, โดยที่ สูตร (i) ประกอบรวมด้วย a องค์ประกอบประเภทโปรตีน, and
5 โดยที่องค์ประกอบประเภทโปรตีนของสูตร(i) ประกอบรวมด้วย one or more, ที่เหมาะสมคือ
at least สอง, ที่เหมาะสมกว่าคืออย่างน้อยสาม, ที่เหมาะสมกว่าอีกคืออย่างน้อยสี่, ที่เหมาะสมที่สุดคือ
at least five, ที่เหมาะสมกว่าอีกคืออย่างน้อยsix, ที่เหมาะสมที่สุดคือ all of the following amino
acidsสำหรับทุก 100 กรัมของโปรตีน inองค์ประกอบประเภทโปรตีน: