D-alanyl-D-lactate does not readily bind vancomycin and thus provides resistance to it. The D-lactate is lost in transpeptidation so the final composition of the peptidoglycan is the same. The vanA operon also encodes a D,D-carboxypeptidase,
D-alanyl-D-lactate does not readily bind vancomycin and thus provides resistance to it. The D-lactateis lost in transpeptidation so the final composition of the peptidoglycan is the same. The vanA operon also encodes a D,D-carboxypeptidase,