the skin luminosity of each region was measured using a Chroma
Meter (CR-200, Minolta Camera, Tokyo, Japan).
L*, the change in luminosity index L*,
was calculated as L* = pre-exposure L*−L* of reading on each measurement day after exposure.
The effect of hesperetin microemulsion on skin depigmentation was evaluated
using L* as an index.
The animals were cared for according to the guidelines for the Care and Use of Laboratory Animals of the Kaohsiung Medical University.