A B S T R A C T
parameters on mean effect of different high pressure homogenization energy input emulsions were diameter droplet (MDs) and droplets of lipid injectable different All emulsions were prepared at different water bath temperatures or at and rotor-stator rotation speeds system times, and using different homogenization pres sures and numbers of high-pressure system The MDs and polydispersity index (P) value of the emulsions were determined using the dynamic light scattering (DLS) method, and large-diameter assessments were performed using the light-obscuratio single particle optical sensing (LosPos) method. Using 1000 bar homogenization pressure and seven the energy input parameters related to the rotor-stator system will have an effect on the final particle size results. When rotor-stator system energy input parameters are homogenization pressure and recirculation will affect mean particle size and large diameter droplet. Particle size will decrease with increasing homogenization pressure from 400 bar to 1300 bar when homogenization recirculation is fixed; when the homogenization pressure is fixed at 1000 bar, the particle size of both MDsand percent of fat droplets exceeding s um (PFATs will decrease with increasing homogenization recircula tions, MDs dropped to 173 nm after five cycles and maintained this level, volume-weighted PFATs will drop to 0.038% after three cycles, so the "plateau" of MDs will come up later than that of PFAT's, and the optimal particle size is produced when both of them remained at plateau. Excess homogenization recirculation such as nine times under the 1000 bar ma lead to PFAT's increase to 0.060% rather than a decrease; ther ore, the high-pressure mogenization procedure is the key factor affecting the particle size distribution of emul sions. Varying storage conditions 2s also influenced particle size, especially the ght o 015, Food and Drug Administration, Taiwan. Published Taiwan by Elsevier LLC. All rights reserved.