Overview of microarray data
Considering the biological difference between H9N2 viral infection and viral particle treatment,we inoculated HUVECs with H9N2 viruses and inactivated viral particles,respectively,and observed the global patterns of gene expression using microarray
technology at 24 h after inoculation. Microarray analysis showed that H9N2 virus infection induced an abundance of DEGs when compared to its control, exhibiting a transcriptional signature of viral infection. H9N2 virus infection induced 6300 of DEGs. Of these DEGs,2091
wereup-regulated and 4209 were down-regulated.In a striking contrast, inoculation with H9N2 viral particles yielded a much smaller numbers of DEGs,indicating a non-infectious transcriptional signature. clearly showed the huge difference in the number of DEGs between H9N2 virus infection and viral particle treatment.