Patientswith NASH are at risk of developing progressive
fibrosis; reported in up to 50% of cases over 6 years [3]. There is
increasing recognition that NAFLD is a heterogeneous diseasewithmultiple
pathways of pathogenesis and patients with different phenotypes
of NAFLDcan presentwith diverse diseasemanifestations [4]. Insulin resistance
plays a dominant role in the pathogenesis ofNAFLD [5]. Patients
with type 2 diabetesmellitus (DM) have an increased risk of developing
NAFLD, NASH and hepatic fibrosis/cirrhosis [6–9]. Furthermore, NAFLD
patients with DM have three times the mortality compared to non-