In an effort to illustrate the dissolution behavior of in situ coated particles 50 mg of spray-dried sample was added to 1ml of water (18 ◦C) in a 1.5 ml vial. The sealed vials were continuously rotated on a Heidolph Duomax 1030 rocking table (Rose Scientific 1030, Edmonton, Canada) and the time for dissolution, as determined by visual inspection, was recorded