This study was aimed to investigate if treatment-related success in weight loss (i.e., reductions of BMI
and fat percentage) is linked to significant changes in choice evoked brain activity in adolescents with
excess weight. Sixteen adolescents with excess weight (age range: 12e18; BMI range: 22e36) performed
the Risky-Gains Task during functional Magnetic Resonance Imaging (fMRI) both before and after a 12-
week weight loss intervention. Success in weight loss was selectively associated with increased activation
in the anterior insula. We concluded that adolescents with the greatest increases in activation of the
insula-related interoceptive neural circuitry also show greater reductions in BMI and fat mass.