In this investigation, we have demonstrated the antibacterial activity of A. vasica leaf extract and the involvement of the systemic resistance induction against bacterial leaf blight disease caused by X. oryzae pv. oryzae in rice. In conclusion, our study results suggest that A. vasica leaf extract has strong in vitro inhibition against Xoo and has reduced the BLB disease under greenhouse condition. In contrast, the pronounced recovery growth, productivity and defense enzyme enhance the A. vasica leaf extract in minimizing seedborne bacterial leaf blight disease in rice. Therefore, we recommend the use of A. vasica in order to control seedborne bacteria, Xoo and development of disease, in that the use of A. vasica leaf extract is environmentally safe in the management of seed-borne bacterial leaf blight disease in rice.