Here we review some of the recent literature on nanoparticleprotein
interactions in light of the fact that the biological impacts
of nanoparticles are affected by the nature of the adsorbed protein
layer, or the protein (biomolecule) corona. With the potential uses of
nanoparticles in biological applications such as nanomedicine being
well known, and the increasing importance of the emerging field
of nanotoxicology, which aims to address the safety of engineered
nanoparticles, the relevancy of protein-nanoparticle interactions
cannot be overstated. While most of the knowledge regarding proteinnanoparticle
interactions is from solution and in vitro studies, it is clear
that future directions will require studies under competitive binding
conditions such as occur in vivo.