Abstract
Methanolic
extract
Piper
sarmentosum
Roxb
. Piperaceae
leaves
was
studied
for
neuromuscular
blocking
activity
rat
phrenic
nerve
hemidiaphragm
preparations
plant
extract,
concentrations
and
exhibited
initially
transient
increase
twitch
tension
which
was
followed
marked
dose
related
neurally
evoked
twitch
depression
neuromuscular
blocking
effect
produced
plant
extract
was
compared
withr
tubocurarine
and
succinylcholine
neurally
evoked
twitch
depression
extract,
was
and
respectively
neurally
evoked
twitch
depression
produced
extract
partially
antagonized
tetraethylammonium
but
not
neostigmine
These
findings
suggested
that
plant
extract
possessed
marked
neuromuscular
blocking
activity
neuromuscular
junction
possible
mechanism
which
likely
inhibit
neurotransmitter
(acetylcholine)
release
presynaptic
terminal
Elsevier
Science
Ireland
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