We identified candidate studies by conducting computerized
searches of the Medline and Web of Science databases using the
terms “aspirin,” “acetylsalicylic acid,” “salicylates,” “adenoma,”
and “randomized clinical trial.” We also consulted with colleagues
to identify unpublished studies that may exist. We included all
placebo-controlled randomized trials of aspirin (acetylsalicylic
acid) in any dose as a chemopreventive agent for sporadic largebowel
adenomas.