and that the crude MeOH and CHCl3 alkaloid extracts showed significant antiplasmodial activity
against chloroquine and antifolate resistant Plasmodium falciparum strains: TM4/8.2 and K1CB1
(Wangchuk et al., 2011). This prompted us to investigate the alkaloid constituents of C. dubia with a
view to generate potential new therapeutic agents and at the same time validate the use of this plant in
Bhutanese traditional medicine (BTM) for the treatment of malarial or microbial infections