There were no changes in Hb levels although in in vitro study,
curcuminoids showed the protective effect of RBC from free radicalinduced
hemolysis in a concentration-dependent manner [59].
However, this effect in vivo may be uncertain because of extremely
low bioavailability as a consequence of poor solubility of curcumin in
an aqueous condition and rapid metabolism in liver and intestine
[60]. After single dose if 2 g curcumin for 1 h, undetectable or very
low level (0.006±0.005 μg/mL) was found in human serum [61].
Several clinical studies confirming the poor bioavailability of
curcumin administered at various dosages were also reported in
Anand et al. [60].