Introduction
How nanometer-scale molecular components construct
micron-scale cells of specific shapes and sizes remains an
outstanding question in biology. How are cell shapes generated?
Are there reasons why cells have adopted certain
shapes over others? Although many shape-determining factors
have been identified across divergent organisms, mere
characterization of individual cellular components has not
revealed how shape is determined, nor has it provided much
insight into the context under which these shapes evolved.
Addressing these questions will require the integration of
biology, physics, and chemistry. For instance, in addition to
traditional molecular cell biology, it will be important to
understand the role of cellular mechanics, the material
properties of cells, their microenvironment, and evolutionary
constraints. Comparisons among organisms with a common
shape may help to reveal general principles that dictate
shape determination and its evolutionary origins.
IntroductionHow nanometer-scale molecular components constructmicron-scale cells of specific shapes and sizes remains anoutstanding question in biology. How are cell shapes generated?Are there reasons why cells have adopted certainshapes over others? Although many shape-determining factorshave been identified across divergent organisms, merecharacterization of individual cellular components has notrevealed how shape is determined, nor has it provided muchinsight into the context under which these shapes evolved.Addressing these questions will require the integration ofbiology, physics, and chemistry. For instance, in addition totraditional molecular cell biology, it will be important tounderstand the role of cellular mechanics, the materialproperties of cells, their microenvironment, and evolutionaryconstraints. Comparisons among organisms with a commonshape may help to reveal general principles that dictateshape determination and its evolutionary origins.
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