Efficacy While the use of antimicrobial prophylaxis in
low-risk procedures (i.e., those with no active labor and no
rupture of membranes) has been brought into question by
the results of several randomized, placebo-controlled studies that found no reduction in infectious complications (fever, SSI, urinary tract infection, or endometritis) with the
use of prophylaxis, the majority of these evaluations were
underpowered and included administration of antimicrobial
prophylaxis at cord clamping.
593–599
However, the efficacy
of antimicrobial prophylaxis in cesarean delivery has been
shown in several studies and two meta-analyses for both
elective and nonelective procedures. Therefore, prophylaxis
is recommended for all patients undergoing cesarean delivery.