Figure 2. Effect of intrathecal propentofylline on SNL-induced
neuropathic pain. Graph A shows a dose-dependent effect of
intrathecal propentofylline on SNL-induced neuropathic pain. Intrathecal
propentofylline (0.5 or 2.5 mg/rat) markedly raised the pain
threshold, whereas, intrathecal propentofylline 0.1 mg/rat didn’t show
obvious effect on SNL-induced allodynia. Graph B means the
percentage of anti-allodynia of the maximum possible effect. The Yaxis
is the percentage of the antiallodynia after drug administration. %
Antiallodynia = 10021006(baseline of SNL-Drug – post SNL-Drug)/
(baseline of SNL-Saline – post SNL-Saline). *P,0.05, compared with
that of SNL-Saline. #P,0.05, compared with that of SNL-P 0.5 mg group.
6 rats in each group. P: propentofylline.
doi:10.1371/journal.pone.0072943.g002