3.3. Impact of strain genotype on pDNA purificationWhile the choice of production strain directly affects the pDNAfermentation yield, it might affect pDNA purification as well as aresult of alterations in the ratio between plasmid and impurities.As earlier reviewed, strain engineering can increase pDNA per-centage per cell, reduce genomic DNA and RNA impurities, anddecrease process stream or lysate viscosity (Bower and Prather,2009). Moreover, a carefully designed strain may result in improvedplasmid