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In conclusion, this study has demonstrated that the traditional fermentation of the local sorghum varieties resulted in a significant reduction trypsin and amylase inhibitory activities, phytic acid and tannin contents. Fermentation was also found to significantly improve in vitro protein digestibility. These results clearly indicate that fermentation may be useful for improving the nutritional quality of the sorghum with respect to protein and carbohydrate utilization as well as mineral bioavailability.